OPTIONS X
28 August - 01 September 2019
1 Raffles Blvd, Singapore 039593
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Opening remarks by Dr Liang Xiao Feng
Part 1: Animal and Zoonotic Influenza in China
Tea Break
Part 2: Pharmaceutical Research in China (with a Focus on Chinese Medicine)
Influenza Transmission in Experimental and Field Settings
Pathogenesis and Transmission of Emerging Influenza Viruses
Implications of Incomplete Viral Genomes for Influenza A Virus Fitness
Rapid Molecular Point of Care Tests: Strategies for Use
Shifting the Diagnostic Paradigm from Pathogen to Host
Innovation in Pandemic Influenza Response
Do Influenza Vaccines Attenuate the Severity of Breakthrough Infections?
Impact on Cardiovascular Outcomes
Abstract No 10440 - Autophagy-mediated Restriction of Avian Influenza Virus Replication in Mammalian Cells
Abstract No 10855 - Haemagglutinin Mutation and Higher Neuraminidase Activity Enhanced the Adaption of H5N6 Avian Influenza Viruses to Mammalian Hosts
Abstract No 10945 - Assessment of Zoonotic Transmission of Swine Influenza A Viruses from Pigs to Naïve or Vaccinated Ferrets
Abstract No 10563 - The Impact of Syndromic Molecular Point-of-care Testing for Respiratory Viruses in Adults Presenting to Hospital with Exacerbation of Airways Disease: Further Analysis from a Randomised Controlled Trial
Abstract No 10565 - Evaluation of the Febridx Host Response Point-of-care Test to Differentiate Viral from Bacterial Aetiology in Adults Hospitalised with Acute Respiratory Illness During Influenza Season
Abstract No 10311 - Variations in Seasonal Influenza Vaccine Effectiveness due to Biological Characteristics: A Systematic Review and META-analysis of Test-negative Design Studies
Abstract No 10395 - Vaccine Effectiveness Against Influenza Hospitalization in the 2018-2019 Season: Comparison between Cell-based and Egg-based Influenza Vaccines
Abstract No 10881 - Influenza Vaccine Effectiveness Against Laboratory-confirmed Influenza Mortality in Older Adults
Abstract No 10499 - Relative Vaccine Effectiveness of High Dose Versus Adjuvanted Influenza Vaccine: A Retrospective Cohort Study
Neuraminidase Inhibitors: In Pursuit of Laboratory Correlates of Clinically Relevant Resistance
Antiviral Resistance [Polymerase Inhibitors]
Clinical Studies on Immunopathogenesis
Abstract No 10877: Rapid Molecular Testing for Influenza in Children Improves Patient Management in Acute Care Setting
Abstract No 10750: Seasonal and Other Influenza Viruses with Reduced Susceptibility to Baloxavir and Pimodivir
Explaining Differences in Vaccine Effectiveness and Virus Circulation in the Southern Hemisphere, 2019
Immune Responses to Repeated Vaccination
Variable Effects of Annually Repeated Influenza Vaccination: Evidence, Mechanisms, and Implications
Abstract No 11047: Birth Cohort-specific Vaccine Effectiveness Against Influenza A(H1N1)PDM09 in Seasons with Different A(H1N1)PDM09 Virus Vaccine Components, I-MOVE Multicentre Primary Care Study, Europe, 2013/14 to 2018/19
Abstract No 10983: Viral Genomic Variation and Vaccine Effectiveness across Consecutive Influenza A(H3N2) Epidemics in Canada, 2016-17 and 2017-18
The Potential of Vaccines to Address Antimicrobial Resistance
Bacterial Interactions: The Role of Influenza in the Epidemiology of Pneumonia
Management of Co-infection in Emerging Influenza– Insights from the WHO New Standard Influenza Clinical Management Guidance
Abstract No 10912: Epidemiology of Influenza-associated Community-acquired Pneumonia Admissions: A 7-year Retrospective Cohort Study in Singapore
Abstract No 10904: Evaluating the Window of Susceptibility to Secondary Bacterial Infections Post-influenza Infection in Ferrets
Evolution of Virus-Glycan Interactions
N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses
Defining Correlates of Immunity Against Influenza Using Systems Serology
Abstract No 11089: Influenza A Virus Surface Proteins are Organized to Help Penetrate Host Mucus
Abstract No 10964: Seasonal H1N1 and Antigenically Drifted H3N2 Influenza Viruses that have Limited Binding to Sialic Acid Bind to Phosphorylated High Mannose Glycans from the Human Lung
Inhibiting Viral Polymerase in Treating Influenza: Clinical Updates
Polyclonal and Monoclonal Antibodies for the Treatment of Influenza
Management of Antiviral Resistance: Lessons from the Transplant Population
Abstract No 10753: Emergence of Viruses with Reduced Susceptibility to Baloxavir Marboxil: Impact on Clinical and Virologic Outcomes in Patients with Influenza at High Risk of Complications (Capstone-2)
Abstract No 10900: Neuraminidase-targeted Hapten Immunotherapy to Treat Influenza
Forecasting Seasonal Influenza Activity
Building a Forecasting Capability for Australian Public Health
Forecasting Virus Strains
Abstract No 11184: Globalization complicated Emergence and Spread of H3N2 Seasonal Influenza A Viruses
Abstract No 10347: FluSight: Six Seasons of Forecasting Influenza in the United States, 2013–14 to 2018–19
The Influenza Virus Neuraminidase as a Vaccine Target
Next-generation Broadly Reactive Influenza Vaccines
T Cell Vaccines against Influenza
Abstract No 11170: Characterising human memory B cells with cross-lineage recognition of the influenza B hemagglutinin following seasonal immmunisation
Abstract No 11110: Intranasal M2SR (M2-deficient single replication) influenza vaccine induced protection against challenge with a substantially drifted H3N2 virus in a phase 2 study
Abstract No 10535: A human broadly cross-reactive anti-neuraminidase antibody protects against different subtypes of influenza A and B viruses in the mouse model
Abstract No 10880: Pre-existing immunity to the conserved hemagglutinin stalk of influenza virus may drive selection for an escape mutant virus in humans
Abstract No 10980: RNACTIVE©: A promising mRNA based influenza vaccine
Adjuvant Therapy for Severe Influenza Infection
Adjuvant Use of Corticostroids in Influenza and Pneumonia
Potential Host Targeted Therapies in Influenza
Abstract No 11025: Development of a new class of broad spectrum influenza PB2 inhibitors
Abstract No 11127: Intravenous Peramivir in emergency department high-risk patients with influenza: A multicenter randomized controlled study
Abstract No 10475: Human-to-human transmission of influenza A(H3N2) viruses exhibiting reduced susceptibility to Baloxavir due to a PA I38T substitution in Japan
Abstract No 11286: Pharmacokinetics of Favipiravir (T-705) in combination with Oseltamivir for treatment of critically ill patients with severe influenza
Abstract No 11217: A Randomized controlled trial on the effect of fever suppression by antipyretics on influenza
Strategies to Enhance Local Protective Influenza-Specific Immunity in the Respiratory Tract
Comparative Immunogenicity of Enhanced Influenza Vaccines in Older Adults in Hong Kong: A Randomized Controlled Trial (PIVOT)
Abstract No 10390: Serologic response to sequential influenza vaccination in older adults from a randomized trial
Abstract No 11171: Prior infection enhances the magnitude and breadth of anti-H3N2 antibody responses to influenza vaccination and reduces the risk of subsequent A/H3N2 virus infection
Abstract No 10609: Does strain change influence vaccine effectiveness against influenza A (H3N2)?
Abstract No 10561: Repeat vaccination reduces antibody affinity maturation irrespective of influenza vaccine platform in humans
Abstract No 10385: Comparison of influenza antibody titers among women who were vaccinated in the 2nd and 3rd trimesters of pregnancies
Abstract No 10375: Heterologous prime-boost using AS03 adjuvanted A(H5N1) pandemic stockpiled influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost
Human CD8+ T Cell Cross-reactivity Across Influenza A, B and C Viruses
How the Host Response Determines Disease Outcome after Influenza Virus Infection
Ten Years After the 2009 "Swine Flu" Pandemic: a Perspective from a Veterinary Biomedical Researcher
The Pandemic Matrix Gene Enhances Innate Immune Responses during Infection
The Emergence, Epidemiology and Evolution of the H3N8 and H3N2 Canine Influenza Virus
Repeated Outbreaks of H5 Highly Pathogenic Avian Influenza in Wild Birds and Poultry in Europe between 2014 and 2019
Abstract No 10528: Annotation and recovery of ferret-specific immunoglobulin sequences
Abstract No 10490: Broadened cross-reactive immunity in ferrets after repeated influenza A/H3 exposures
Abstract No 10471: Molecular and functional dissection of the influenza virus-specific CD8+ T-Cell receptor repertoire during aging
Abstract No 11198: Improving avian influenza surveillance through wetland sampling
Abstract No 11035: Innate-like signatures of influenza-specific CD8+ resident memory T cell responses in the human lung
Abstract No 11253: Repeated crow (corvus spendens) mortality events linked to H5N1 influenza virus circulation in live bird markets, Bangladesh
Abstract No 11216: Subdominance and diminished tfh elicitation constrain humoral immunity against the influenza Ha-stem
Abstract No.11794: Characterizing the functionality of the Wuhan Spiny Eel Influenza Virus surface Glycoproteins
Abstract No. 10355: Low literacy program for safe slaughter of poultry in developing countries to reduce human infection with avian influenza virus
Contagious Phenotypes of Influenza Virus Infection
Spread of Pandemic Influenza in US Communities in 1920 and 2009: What Changed in the Last Century?
Abstract No 10910: Quantifying the effects of school closures on mitigation of influenza epidemics in Hong Kong
Abstract No 10466: Access to Telework, Paid Leave Benefits, and Work Attendance in Adults with Medically-Attended Acute Respiratory Illness (ARI)
Impact of Influenza Vaccination During Pregnancy on the Mother, Fetus and Infant
Influenza and Older Adults: Frailty, Function and Healthy Ageing
Abstract No 11754: A global, randomized, double-blind, placebo-controlled study evaluating safety and efficacy of VIS410 in combination with OSELTAMIVIR versus OSELTAMIVIR alone in hospitalized adults with influenza a requiring oxygen
Abstract No 10812: Reduced susceptibility viruses to baloxavir marboxil: Prognosis factors of the emergence and impact on clinical and virologic outcomes in pediatric patients in Japan
Influenza in Children: Challenges and Unanswered Questions
Abstract No 11756: Single-dose Baloxavir is well tolerated and effective for treatment of influenza in otherwise healthy children aged 1 to <12 years: A randomized, double-blinded, active-controlled study (miniSTONE-2)
Abstract No. 10108: The Bat Influenza H17N10 can be Neutralized by BNMABS and its NA Facilitates Viral Egress
Abstract No 11718: Single-dose Baloxavir for the Prevention of Influenza among Household Contacts: A Randomized, Double-blinded, Placebo Controlled Post-Exposure Prophylaxis Study (BLOCKSTONE)
Epidemiological Consequences of Immune Memory
Influenza in Context: Insights into Universal Vaccination Against Influenza
Using Serological Data to Reconstruct Historical Influenza Dynamics
Abstract No 11088: Effect of maternal pandemic vaccination on seroprevalence against influenza in children at birth and at 4 years
Abstract No 11349: Risk factors and attack rates of seasonal influenza infection: Results of the SHIVERS Seroepidemiologic cohort study
Abstract No 11206: Serosolver: An open source tool to infer epidemiological and immunological dynamics from serological data
Abstract No 11162: Antibody response and influenza-like illness among healthcare workers after influenza vaccination
Abstract No 11051: Hemagglutinin and neuraminidase antibodies are induced in an age- and subtype- dependent manner after influenza virus infection.
Fighting Influenza from a One Health Perspective
Emergence of Swine Influenza in Australia
Abstract No 11345: Lower cognition among toddlers who experience acute respiratory illnesses in Panama and El Salvador
Emergence of Avian Influenza Viruses in Asia
Reverse Genetic Analysis of Bat Influenza Viruses: A Journey Full of Surprises
Abstract No 11179: Few substitutions of H5 gene belonging to Clade 2.3.4 have altered the NA gene preferences of the virus other than N1
Abstract No 10649: Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans
Abstract No 10960: Mitigating pandemic risk with influenza A virus field surveillance: MIA (Mobile Influenza Analysis)
Abstract No 11300: Long-Term Care/Nursing Home admission following hospitalization with influenza and acute respiratory illness: The role of social vulnerability. A report from the Canadian Serious Outcomes Surveillance Network
Influenza Vaccination of the Immunocompromised
Abstract No 10712: Effect of treatment with neuraminidase inhibitors on the risk of in-hospital death among influenza patients reported from EU countries, 2010–2019
On Waning and Boosting: Is There a Sweet Spot for Influenza Vaccination Strategies in the Tropics?
Abstract No 10324: Vaccine induced mucosal IgA contributes to protection against influenza infection in humans
Abstract No 11083: Towards an improved wild-type sequence based hemagglutination inhibition assay for the evaluation of influenza vaccines: challenges and new developments.
Abstract No 10944: First-in-man clinical trials of influenza vectored vaccines against tuberculosis with intranasal and sublinqual routes of administration
Abstract No 10937: OVX836, A novel universal influenza A vaccine candidate: First results of a phase I clinical trial in humans
Abstract No 11163: Impact of antiviral therapy on short- and long-term outcomes of patients with Copd following influenza infection
Abstract No 11095: Immune history to influenza is a novel correlate of protection of influenza vaccination
Abstract No 11161: Treating influenza with antivirals is associated with a decreased burden of complications and health resource utilization in high risk patients
Abstract No 11073: Induction of broadly cross-reactive immune responses against A(H3N2) viruses: results of a phase 2 trial of a novel recombinant hemagglutinin saponin-adjuvanted nanoparticle influenza vaccine
Healthcare Outbreaks of Influenza
Deep Sequencing and Mapping Chains of Transmission
Abstract No 10448: Preliminary estimates of the incidence of influenza-associated acute respiratory infection among adults aged >60 years in a multi-site community cohort in India
Efficacy of Live-attenuated Vaccines
Abstract No 10352: Influenza virus transmission from symptomatic and asymptomatic individuals in a rural and an urban setting, South Africa, 2016-2017
Abstract No 10702: Impact of influenza antigenic evolution on disease dynamics in the United States
Influenza Vaccination of Children – What Have We Learnt?
Abstract No 10492: Determinants of influenza transmission in households in rural North India
Abstract No 11200: Effect of host genetic polymorphism on transmission of influenza virus infection in a household setting
Abstract No 10811: The United Kingdom’s childhood influenza vaccination programme: Review of uptake and vaccine effectiveness over the first six seasons
Abstract No 11001: The Epidemioloogical Signature of the influenza B/Victoria and B/Yamagata Lineages in the 21st Century
Abstract No 11195: Impact of the introduction of the paediatric live attenuated influenza vaccine (LAIV) programme: An intercountry comparison across the United Kingdom and the Republic of Ireland
Abstract No 10913: First trimester seasonal influenza vaccination and major congenital malformations: A 2010-2016 UK retrospective cohort study
Abstract No 10749: Viral shedding in recipients of live attenuated influenza vaccine in the 2016/17 and 2017/18 influenza seasons in the United Kingdom
Abstract No 10376: Cost-effective analysis for influenza vaccination coverage and timing in tropical and subtropical climate settings: a modelling study
Abstract No 10332: Costs and effects of childhood influenza vaccination in the Netherlands: important risk of undesirable effects
Next Generation Orally Efficacious Influenza Drug Candidate with High Genetic Resistance Barrier
Structural Snapshots of Actively Transcribing Influenza Polymerase
The Interplay between Influenza and Cellular Sphingolipids
Abstract No 11313: Dissecting the mechanism of signaling-induced nuclear export of influenza virus vRNPs
Abstract No 10698: Differential regulation of Post-Translational Modification (PTM) status of influenza A viral Ribonucleoproteins (RNPs) during different stages of the viral life cycle
Lessons and Experience of Clinical Diagnosis and Treatment on Avian Influenza Cases in Guangzhou, China
Zoonotic Transmission of Influenza A Viruses at Agricultural Fairs
Clinical Features of Influenza A(H5N1) Infection and Other NA Subtypes
Abstract No 10853: Incidence and seroprevalence of avian influenza viruses among Egyptian backyard poultry growers: Results from a prospective cohort study
Abstract No 10966: Clinical evaluation of adjuvanted recombinant hemagglutinin H7 vaccine to highly pathogenic A(H7N9) influenza virus
Pandemic Severity Assessment
Disease Severity in Influenza and Other Respiratory Viral Infections
The FLU-CATs Study - Validation of Triage Tools for use Across a National Healthcare System During Surge in Healthcare Demand Due to Pandemic Influenza
Abstract No 11254: Burden and severity of influenza-like illness in Australia: 10 years of flutracking online surveillance
Abstract No 10547: Estimating the influenza disease pyramid in Singapore
Virology and Pathogenesis Poster Session + Networking
Immunity to Influenza in Dirty Mice
Obesity as a Risk Factor in Influenza Virus Infection
ANP32 Proteins: Host Factors that Impact Influenza Virus Polymerase Activity and Host Range
Abstract No 10428: Spatial and temporal quantification of putative lung regenerating cells during early recovery from influenza pneumonia
Abstract No 11138: Obesity increases the cardiac complications of influenza virus infection
Influenza in the Tropics
"Seasonality" of Influenza in the Tropics Due to Waning of Protection
Monitoring Influenza Activity and Burden in the Tropics
Abstract No 11211: Resistance development in influenza a viruses infecting mallards exposed to low levels of Peramivir
Abstract No 10100: Live attenuated influenza vaccine induces early tonsillar follicular t helper cell responses correlating with durable systemic antibody responses
Effectiveness of Influenza Vaccination in Different Populations
Rational Policy for Neuraminidase Inhibitors
Evolutions of National Influenza Immunization Program in the Republic of Korea
Evidence Needed to Accelerate Influenza Vaccine Introduction into National Immunisation Programme in China
Abstract No 11112: A history of obesity reduces the immune response to influenza virus in an NLRP3 dependent manner
Abstract No 10740: Repeated seasonal influenza vaccination results in reduced protection against influenza A(H3N2) infection in ferrets compared to single vaccination
Abstract No 10591: MHC class II proteins mediate cross-species entry of bat influenza viruses
Abstract No 11289: Development of a universal Influenza A T cell-based vaccine
Abstract No 11792: Prevention of Influenza during Mismatched Seasons in Older Adults: a Randomized Efficacy Study of an MF59-Adjuvanted Quadrivalent Influenza Vaccine
Abstract No 11748: Vaccination with 1/6th standard dose of a split inactivated influenza vaccine using a high-density micro-projection array patch induces comparable immune responses to conventional full-dose intramuscular injection; results from a phase
Panel Discussion on Overcoming Challenges for Implementation of Prevention and Control of Seasonal Influenza
How Antiviral Proteins can Stimulate Influenza Virus Replication
Visualizing Influenza Virus Assembly
Mini Viral RNAs: Consequences of RNA Structure for Genome Replication and Innate Immune Sensing
Abstract No 11735: Immunogenicity of chimeric hemagglutinin-based universal influenza virus vaccine candidates: interim results of a randomized, placebo-controlled, phase 1 clinical trial
Abstract No 10606: New genomic approaches to understand the heterogeneity of viral replication in single cells
Abstract No 10843: ANP32 proteins from different mammalian species act as host range barriers and shape influenza polymerase adaptation
Non-pharmaceutical Public Health Measures for Mitigating the Risk and Impact of Epidemic and Pandemic Influenza
Policy Considerations for Pandemic Preparedness and Response
Policy Considerations for Pandemic Preparedness and Response Planning: Thailand’s Experiences
Panel Discussion on Overcoming Challenges for Pandemic Preparedness Planning
Insight into Host-pathogen Interactions in the Upper Respiratory Tract from Live Attenuated Influenza Vaccine Studies in Children
Mucosal Immunity in Pathogenesis and Protection Against Human Influenza Infection Challenge
Harnessing the Host Response to Generate Biomarkers for Influenza and Other Respiratory Tract Infections
Abstract No 11082: Correlates of protection for better, faster influenza vaccine development
Abstract No 10943: Pre-existing NP specific T-cell response correlates with reduction of symptoms in a human Influenza challenge model
Mapping Selection on Influenza Virus from Polyclonal Human Serum
Influenza in the Age of Mammals
Evolution of Seasonal Influenza Viruses
Abstract No 10822: The evolutionary dynamics of influenza A and influenza B viruses in naturally infected human hosts
Abstract No 10995: Predicting evolutionary pathways to ‘fit’ oseltamivir resistant influenza viruses
REMAP-CAP: A Platform Trial to Advance Knowledge of Optimal Treatment for Critically Ill Patients with Influenza
Neurological Complications Associated with Influenza
Cardiovascular Complications of Influenza
Abstract No 11151: Potential therapeutic role of bone marrow-derived mesenchymal stem cells in acute lung injury induced by highly pathogenic avian influenza virus A/H5N1
Abstract No 11309: Baloxavir for the treatment of Influenza virus infection in hematopoietic stem cell transplant recipients who failed oseltamivir
Influenza Burden and Links to Policy - Building the Pyramid
Global Estimates of Influenza-associated Hospitalization from the InfluEnza BurdEn, Global Project (IcEBErG)
Abstract No 11044: The burden of in-hospital and out-of-hospital deaths among patients hospitalized with influenza, FluSurv-NET, 2010–2016
Abstract No 10858: Estimating the number of deaths due to Influenza — An alternative to regression-based estimates of excess influenza mortality
Abstract No 10667: Community burden of influenza in a rural and an urban setting, South Africa, 2016-2017
Abstract No 10362: Under-detection of laboratory-confirmed influenza-associated hospitalizations among infants in a multi-country prospective study
Lunch Distribution
Changing The Paradigm: The Domino Effect of Influenza - Beyond the Respiratory Disease
Cardiovascular Complications of Influenza
Evaluating the Impact of Influenza Vaccines on Cardiovascular Outcomes - An Industry Perspective
Collection of Lunch Boxes
Lunch Distribution
Identifying the Threats: Evaluating the Unmet Needs in Influenza vaccination
Protecting Against an Elusive Enemy: The Challenge of Strain Mismatch and Egg Mutagenesis
Shielding the Vulnerable: Improving Effectiveness Through adjuvanted vaccines
Defending Against the Threat of a Pandemic: How Prepared Are We?
Closing
Collection of Lunch Boxes
Lunch Distribution
Burden of Paediatric Influenza
Efficacy and Safety of an Inactivated Influenza Vaccine in the Paediatric Population
Paediatric Influenza Vaccination: Recommendations and Implementation
Discussion and Q&A
Welcome
Influenza Transmission: Insights From the Primary Care Perspective
Transmission in Animal Models: What Have We Learned from the Ferret?
Transmission in Humans: Learnings and Limitations
Panel discussion and Q&A
Summary and Close
Welcome and Introduction
Dinner Distribution
Collection of Dinner
Collection of Lunch Boxes
Collection of Lunch Boxes
Welcome Address from the Chair, Options X
Welcome Address from the Chair, ISIRV
Opening Address by Guest-of-Honour
Presentation of ISIRV Awards
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