MSPTM 2019 Annual Scientific Conference
13 - 14 March 2019
InterContinental Kuala Lumpur

Abstract

Title
OVERCOMING THE DENGUE CHALLENGES USING WOLBACHIA STRATEGY
Type
Oral Presentation - Invited Speaker
Theme
Scaling Up Efforts in Tropical Disease and Vector Control through Evidence-Based Research
Topic
Dengue

Authors

Main Author
Nazni Wasi Ahmad 1
Presenting Author
Nazni Wasi Ahmad 1
Co-Author
Noor Afizah A.1
Cheong YL1
Faiz A1
Mohd Arif AK 1
Mohamad Irwan MS1
Irfan MN FR1
Kamarul MRG1
Nizam MMN1
Thohir H1
Nuradila N1
Nur Ruqqayah MM1
Nur Syamimi HS1
Nur Zatil Aqmar MZ1
Rubaaini S1
Siti Nor Syazwani Amran1
Fadzilah K1
Lee HL1
Gill BS1
Mohammad Nazarudin B1
Hasnor HA2
Abu Bakar R2
Hapsah MD2
Normawati A2
Mohd Nasir A2
Khadijah K3
Lee SC 3
Paid M3
Ruziyah O4
Shreema R4
Hoffmann AA5
Sinkins SP6

Authors' Institution

Department / Institution / Country
Medical Entomology Unit, Infectious Disease Research Centre / Institute For Medical Research / Malaysia1
Institute for Health Behavioural Research (IPTK) / Institute for Health Behavioural Research (IPTK) / Malaysia2
Petaling District Health Office / Petaling District Health Office / Malaysia3
Gombak District Health Office / Gombak District Health Office / Malaysia4
Departments of Zoology and Genetics / The University of Melbourne / Australia5
MRC-University of Glasgow Centre for Virus Research / University of Glasgow / United Kingdom6
Content
Abstract Content

Dengue is a serious Aedes borne disease common in many tropical and sub-tropical countries including Malaysia. Presently, specific anti-viral treatment and an effective tetravalent vaccine against all dengue serotypes are still unavailable. Reducing abundance of the primary vector mosquito Aedes aegypti remains the main approach used for dengue virus control, but is relatively ineffective. Hence, the Wolbachia strategy using wAlbB strain was used to control the dengue transmission. Releases were conducted in 7 hotspots in PKD Petaling and PKD Gombak, Selangor which is AU 2 Keramat, PKNS Flat AU2,  Keramat,  Flat PKNS Seksyen 7 Shah Alam, jlan Plumbub 101/103, Mentari Court, Kelana Jaya, Petaling Jaya, Pusat Komersial, Shah Alam and Jalan Kristal Shah Alam.  Site selection criteria were formulated to maximise to evaluate the wolbachia strategy in the real time situation. The study indicated that  areas where releases were undertaken were rapidly invaded (6-10 weeks) by Wolbachia and in some sites though releases has been stopped  for 11 months the frequency of Wolbachia was more than  90 %. A trend of reduction in the range of 50-80% of dengue cases was observed in the release sites in comparison to the control sites indicating that replacement strategy does block local dengue transmission in the release areas.   

Keywords:
Requires Audio or Video system for Presentation?: Yes