MSPTM 2019 Annual Scientific Conference
13 - 14 March 2019
InterContinental Kuala Lumpur


E-Poster Presentation
Scaling Up Efforts in Tropical Disease and Vector Control through Evidence-Based Research
Emerging Zoonoses


Main Author
Syamsiah Aini Shohaimi1
Presenting Author
Syamsiah Aini Shohaimi1
Faizul Fikri Mohd Yusop1
Bee Leng Leow1
Muhammad Redzwan Sidik1
Geok Huai Ong1
Faizah Hanim Mohd Saied1

Authors' Institution

Department / Institution / Country
Department of Veterinary Services / Institut Penyelidikan Veterinar / Malaysia1
Abstract Content
Avian Influenza (AI) H9N2 has become a major problem in the poultry industry in many countries. Although H9N2 viruses are considered as Low Pathogenic Avian Influenza (LPAI), they pose a significant threat to public health as they are considered viruses with pandemic potential. In the last quarter of 2018, epidemic of H9N2 have been occurring in Peninsular Malaysia not only in village chickens but also in commercial poultry farms. Outbreaks were continuously reported with high morbidity, drop in egg production and reduced weight gain. In the present study, we report the genetic variations and phylogenetic analysis of eight recent H9N2 isolates from states of Negeri Sembilan, Penang, Perak and Melaka. Seven isolates showed 97-98% similarities with Indonesian and Vietnam strains while one isolate from Penang had 96% similarities with the Korean strains. Phylogenetic tree based on hemagglutinin (HA) gene showed that the isolate from Penang was clustered within Korean-like lineage suggesting that it could be derived from the previous strains isolated in Malaysia during 2015 to 2017 while the remaining seven isolates from Negeri Sembilan, Penang, Perak and Melaka were clustered under Y-280-like lineage which is a new introduction in Malaysia. A special note to point out is that at position 226 for these seven isolates, there is an amino acid exchange from Glutamine to Leucine (Q->L) at the receptor binding site indicating that these isolate have the potential to infect mammals including humans. Findings from this study revealed that new introduction of Y280-like lineage in Malaysian strains not only can cause major losses to poultry industry (especially for breeders and commercial layers) but is also potentially infectious to humans. This highlights the necessity of implementing farm biosecurity, continuous and thorough surveillance paired with risk-assessment of circulating H9N2 influenza viruses.
Keywords: LPAI; H9N2; poultry; Malaysia
Requires Audio or Video system for Presentation?: No