MSPTM 2019 Annual Scientific Conference
13 - 14 March 2019
InterContinental Kuala Lumpur

Abstract

Title

ROLE OF INTESTINAL MICROORGANISMS IN HUMAN COLORECTAL CANCER: SPECIAL FOCUS ON BLASTOCYSTIS SP. AND KLEBSIELLA PNEUMONIA

Type
Oral Presentation
Theme
Scaling Up Efforts in Tropical Disease and Vector Control through Evidence-Based Research
Topic
Medical Microbiology & Parasitology

Authors

Main Author
Chandramathi Samudi1
Presenting Author
Chandramathi Samudi1
Co-Author
Suresh Kumar2
Umah Rani Kuppusamy3
Christina Parvinder Kaur1
Bustam Anita4

Authors' Institution

Department / Institution / Country
Department of Medical Microbiology / University of Malaya / Malaysia1
Department of Parasitology / University of Malaya / Malaysia2
Department of Biomedical Science,Faculty of Medicine / University of Malaya / Malaysia3
Faculty Of Medicine Dean's Office, Faculty of Medicine / University of Malaya / Malaysia4
Content
Abstract Content

Globally, colorectal cancer (CRC) incidences and deaths are on the rising trend. In Malaysia, CRC is the second most common cancer and its incidence rate is expected to surpass coronary and pulmonary associated diseases in the coming years. Scientific reports have evidenced that apart from genetic inheritance, infectious organisms including intestinal parasites and bacteria do contribute to the pathophysiology of CRC. Generally, infection may be associated with cancer via two main mechanisms: inflammation and immunosuppression. The common microorganisms that have been directly implicated with CRC include Escherichia coli, Bacteroides fragilis, Shistosoma japonicum and Crytosporidium sp..Besides there microorganisms there are others which are being investigated recently. Here we focused on the role of two main organisms which are Blastocystis sp and Klebsiella pnuemoniae, an intestinal protozoan parasite and bacterium respectively, in the progression or initiation of colorectal cancer. Blastocystis sp. is known as one of the most common intestinal parasites found in any population. There are more than 17 specific small-subunit ribosomal RNA subtypes, of which nine are found in humans. Based on clinical symptoms, the parasite can be further categorized as asymptomatic and symptomatic types. On the other hand, K. pneumonia is a gram negative bacterium that often habitat in the lower GIT track. Numerous studies have reported on the association of these two organisms with irritable bowel disease and irritable bowel syndrome which are the contributing conditions of CRC. However studies on their role as causative agents or promoting agents of CRC are very limited. We have carried out numerous studies that have revealed their role in exacerbating CRC. The results of all experiments carried out thus far will be discussed further.

Keywords: Colorectal cancer, gut pathogens, Blastocystis sp., Klebsiella pnuemoniae
Requires Audio or Video system for Presentation?: Yes