MSPTM 2019 Annual Scientific Conference
13 - 14 March 2019
InterContinental Kuala Lumpur

Abstract

Title

STATUS OF PYRETHROIDS RESISTANCE IN AEDES (STEGOMYIA) AEGYPTI (LINNEAUS) FROM DENGUE HOTSPOTS IN KLANG VALLEY, MALAYSIA

Type
Oral Presentation
Theme
Scaling Up Efforts in Tropical Disease and Vector Control through Evidence-Based Research
Topic
Insecticide Resistance

Authors

Main Author
Siti Futri Farahininajua Fikri1 2
Presenting Author
Siti Futri Farahininajua Fikri1 2
Co-Author
Rosilawati Rasli1
Nazni Wasi Ahmad1
Lee Han Lim1
Wan Kiew Lian2

Authors' Institution

Department / Institution / Country
Medical Entomology Unit / Institute for Medical Research / Malaysia1
School of Bioscience and Biotechnology, Faculty of Science and Technology / Universiti Kebangsaan Malaysia / Malaysia2
Content
Abstract Content

The continued absence of an effective and safe tetravalent dengue vaccine and the lack of specific anti-viral treatment have made mosquito vector control using chemical insecticides as the mainstream for dengue prevention and control.  However, the long-term use of chemical insecticides may induce resistance. Hence detection of insecticide resistance in dengue vectors is crucially important in ensuring the insecticide-based intervention in dengue control program is still effective and reliable. In this study, the susceptibility status of Aedes aegypti from five selected dengue hotspots in Klang Valley, Malaysia against pyrethroids were determined by employing the World Health Organization (WHO) protocol of adult bioassay. Four types of pyrethroids were tested against adult female Aedes aegypti to determine the knockdown rate and post 24-h adult mortality. In addition, the resistance ratio of field-collected Aedes aegypti and a reference susceptible strain was compared.  The adult mortalilty of all strains suggested the presence of cross-resistance within pyrethroids. All field-collected Aedes aegypti strains were resistant to the four pyrethroids tested, except from the strain from Taman Sungai Jelok. Permethrin exhibited the lowest knockdown rate against Aedes aegypti and followed by deltamethrin, cyfluthrin and lambda-cyhalothrin. The detection of resistant Aedes aegypti in most of dengue hotspots in the present study requires further investigation to determine the underlying resistance mechanism(s). The data in this study can be utilized as an input for insecticide resistance management of Aedes aegypti in Malaysia.   

Keywords: Aedes aegypti; insecticide resistance; WHO adult assay; pyrethroids; cross resistance
Requires Audio or Video system for Presentation?: No