MSPTM 2019 Annual Scientific Conference
13 - 14 March 2019
InterContinental Kuala Lumpur

Abstract

Title

ASSOCIATION BETWEEN CRYPTOSPORIDIUM INFECTION AND CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS

Type
Oral Presentation
Theme
Scaling Up Efforts in Tropical Disease and Vector Control through Evidence-Based Research
Topic
Medical Microbiology & Parasitology

Authors

Main Author
Salman Ghaffari2
Presenting Author
Salman Ghaffari2
Co-Author
Narges Kalantari1
Tahmineh Gorgani-Firouzjaee2
Taraneh Ghaffari4
Masomeh Bayani3

Authors' Institution

Department / Institution / Country
Cellular and Molecular Biology Research Center, Health Research Institute / Babol University of Medical Sciences / Iran, Islamic Rep. of1
Department of Mycology and Parasitology / Babol University of Medical Sciences / Iran, Islamic Rep. of2
Infectious Diseases and Tropical Medicine Research Center / Babol University of Medical Sciences / Iran, Islamic Rep. of3
Department of Laboratory Sciences / Babol University of Medical Sciences / Iran, Islamic Rep. of4
Content
Abstract Content

Introduction: Cryptosporidiosis is a parasitic diseases caused by several species of the genus Cryptosporidium. The aforementioned parasite has been suggested as an important opportunistic pathogen in immunocompromised patients. Furthermore,  a relationship between Cryptosporidium infection and cancer has been indicated by a number of epidemiological studies. The current study conducted a systematic review and meta-analysis to assess the prevalence and odds ratios (ORs) of  Cryptosporidium infection in cancer patients in order to further understand this relationship.

Methods: The potential association between Cryptosporidium infection and cancer was evaluated by searching of eligible articles published up to the first of July 2018 using six electronic database including PubMed, Science Direct, Scopus, Google Scholar, ISI Web of Science and Cochrane. In the present study, random effects model and 95% confidence intervals (CI) were used to determine the overall odds ratio (OR). 

Results: In total, 17 studies involving with case-control and cross-sectional designs were included in the present study. The overall random effect favored a significantly increased risk of Cryptosporidium infection in patients with malignancy compared with non-cancer individuals [OR=3.3; 95% CI: 2.08-5.23]. The pooled ORs in case-control and cross-sectional studies were 5.2 [95% CI: 3.10-8.74; χ2=4.83; I2= 0.00%, P=0.681] and 2.12 [95% CI: 1.03-4.73; χ2=15.56; I2=55.0, P=0.029], respectively. A higher ORs was observed in patients with colorectal cancer [OR=3.69; 95% CI: 2.09-6.50; I2=12.5].

Conclusion: This study demonstrated a high prevalence of Cryptosporidium infection in cancer patients compared to non-cancer individuals. It also, showed that colorectal carcinoma may be associated with a higher odds of Cryptosporidium infection. Further studies are recommended to obtain precise results on the relationship between cancer and Cryptosporidium infection. It also suggested that additional experimental studies be performed to improve knowledge of the molecular mechanisms involved in the association between Cryptosporidium infection and cancer.

Keywords: Cryptosporidium spp.; Malignancy; Prevalence; Systematic review; Meta-analysis
Requires Audio or Video system for Presentation?: Yes