Title Sleep Apnoea and Cardiovascular Events after Coronary Artery Bypass Grafting |
Type Young Investigator Award |
Theme ACC Asia & SCS 32nd Annual Scientific Meeting |
Topic Non-Invasive Cardiac Imaging, Echocardiography, Nuclear Cardiology / Adult Congenital Heart Disease / Cardiac Surgery |
Main Author Chieh Yang Koo1 |
Presenting Author Chieh Yang Koo1 |
Co-Author on behalf of the SABOT study investigators 1 |
Department / Institution / Country Cardiology / National University Heart Center / Singapore1 |
Objective(s) Sleep apnoea (SA) is prevalent and independently associated with adverse cardiovascular events after percutaneous coronary intervention. Patients with complex and high-risk features are often referred for coronary artery bypass grafting surgery (CABG) and it remains unknown if SA is a risk marker. We evaluated the association between SA and major adverse cardiac and cerebrovascular events (MACCE) in patients undergoing non-urgent CABG. |
Material and Method This was a prospective cohort study conducted between November 2013 and December 2018. Patients from 3 public hospitals referred to a tertiary cardiac centre for non-urgent CABG were recruited for an overnight sleep study prior to CABG. The mean follow-up duration was 2.1 years. |
Result(s) Among the 1007 patients who completed the study, SA (defined as apnoea-hypopnoea index ≥15 events per hour) was diagnosed in 513 patients (50.9%). Most of the patients underwent on-pump CABG (96.7%) and received a left internal mammary artery graft (95.2%). MACCE, a composite of cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke and unplanned revascularisation, occurred in 123 patients (12.2%). The crude incidence of MACCE was higher in the SA than the non-SA group (15.0% versus 9.5%, p=0.003). Likewise, the crude incidence of all-cause mortality (7.2% versus 4.3%, p=0.028), sudden cardiac death (3.9% versus 1.6%, p=0.028) and heart failure hospitalisations (10.9% versus 5.3%, p=0.001) was higher in the SA than the non-SA group. Multivariate Cox regression analysis demonstrated that SA was predictive of MACCE with an adjusted hazard ratio of 1.54 (95% confidence interval, 1.06-2.22; p=0.023), after adjusting for the effects of age, gender, body mass index, left ventricular ejection fraction, hypertension and chronic kidney disease. |
Conclusion Sleep apnoea is independently associated with increased MACCE in patients undergoing CABG. Further evaluation regarding the efficacy of treatment of sleep apnoea in patients undergoing CABG surgery is warranted. |