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Title RAPID EYE MOVEMENT RELATED OBSTRUCTIVE SLEEP APNEA IN DIABETIC VERSUS NON-DIABETIC PATIENTS TREATED WITH PERCUTANEOUS CORONARY INTERVENTION: RATIONALE AND DESIGN OF SLEEP AND STENT STUDY II |
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Type Free Paper Session 2 |
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Theme ACC Asia & SCS 32nd Annual Scientific Meeting |
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Topic Heart Failure / Cardiovascular Rehabilitation & Preventive Cardiology |
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Main Author Aye Thandar Aung1 |
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Presenting Author Aye Thandar Aung1 |
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Co-Author Chieh-Yang Koo2 Willian Kristanto2 Pipin Kojdojojo2 Calvin Chin3 Chi-hang Lee2 |
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Department / Institution / Country Medicine / NUS / Singapore1 Cardiology / NUH / Singapore2 Cardiology / National Heart Centre / Singapore3 |
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Objective(s) The study aims to determine the prevalence of rapid eye movement (REM) obstructive sleep apnea (OSA) in patients with and without diabetes mellitus (DM) undergoing coronary revascularization. |
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Material and Method The Sleep and Stent Study II is an observational, prospective study. A total of 200 adult patients age 21 to 80 years who underwent percutaneous coronary intervention between 6 and 36 months will be recruited. Recruited patients will undergo an in-laboratory polysomnography (PSG) using a level 1 diagnostic device (Embla RemLogic, Natus Medical Inc. Canada). The PSG tracings will be analyzed by registered polysomnographic technologist and reviewed by sleep physician, both of whom are blinded to patients’ clinical characteristics. The primary measure of PSG is apnea hypopnea index (AHI). The patients will be divided into 2 groups; DM group (n=100) and non-DM group (n=100), and both groups will be adjusted for age, gender and body mass index. |
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Result(s) A total of 110 patients (DM, n=38; non-DM, n=72) had been enrolled into the study as of January 31, 2019. We excluded patients with failed sleep studies (n=2) and central sleep apnea (n=3). According to the preliminary analysis of the first 105 patients (DM, n=34; non-DM, n=71), the prevalence of REM OSA was 24% in the DM group compared to 25% in the non-DM group. Moderate REM OSA (REM AHI: 5-15) was found in 50% of the DM and 61% of the non-DM group, whereas severe REM OSA (REM AHI: >15.1) was found in 38% of the DM and 39% of the non-DM group. |
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Conclusion We expect the study to be completed and the results will be released in late 2019. The result of this study will help us in the understanding of cardiovascular impacts of REM OSA in diabetic patients with coronary artery disease. |