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Title 24-hour urine citrate excretion rates in Asian chronic kidney disease patients and healthy participants without kidney disease. |
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Type Poster Presentation |
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Theme 18th Asian Colloquium in Nephrology (18th ACN 2019) |
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Topic Fluid and Electrolytes |
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Main Author Leanne Leong1 |
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Presenting Author Leanne Leong1 |
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Co-Author Clara Ngoh1 Weng Kin Wong1 Horng Ruey Chua1 Wai Leong Titus Lau1 Boon Wee Teo1 |
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Department / Institution / Country Nephrology / National University Hospital / Singapore1 |
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Abstract Content: Introduction, Method, Result, Conclusion Introduction We compared the 24-hr urine citrate excretion rates (UCER, mmol/day) between chronic kidney disease (CKD) and non-CKD patients in a multi-ethnic Asian population.
Methods We used data from patients with stable CKD from the Asian Kidney Disease Study and normal participants without diabetes or hypertension from the Singapore Kidney Function Study. Participants fasted overnight, and provided a 24hr urine collection, blood sample, and underwent measured glomerular filtration test (mGFR) using 99mTc-DTPA. Standard statistical tests were performed on JMP. Non-normal data was natural log-transformed for analysis. Significance was taken at the 0.05 level.
Results Complete data were available from 187 CKD patients (91 male) and 89 non-CKD participants (42 male). The mean ages were 59±12.8 years and 42±14.3 years in the CKD and non-CKD groups, respectively. The median measured GFR (mL/min/1.73m2) in the CKD and non-CKD groups were 45 (IQR: 29-63) and 100 (IQR: 88-113), respectively (p<0.001). The median UCER was lower in the CKD group compared to the non-CKD group (46, IQR: 11-106 vs. 303, IQR: 206-446). Amongst patients with CKD, UCER decreased with declining mGFR (Log UCER= -1.66+1.37´Log mGFR, p<0.001) and with increasing age (Log UCER=4.73-0.02´age, p=0.02). There was no significant difference in UCER by gender or by ethnicity. UCER was associated with increasing serum carbon dioxide concentration (mmol/L) (Log UCER=-1.63+0.2´serum carbon dioxide, p<0.001) in the CKD group. Mean serum carbon dioxide concentration was lower in the CKD group than the non-CKD group (25.7 vs. 28.3, p<0.001). No participant was on sodium bicarbonate supplementation.
Conclusion UCER is lower in CKD patients compared to healthy participants without CKD. In patients with CKD, UCER decreases with declining mGFR, which is associated with lower serum carbon dioxide concentration, and with increasing age. |