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Title The role of Alpha 2-Heremans-Schmid glycoprotein (AHSG) gene Thr256Ser polymorphisms to aortic calcification on regular hemodialysis patients in Medan, Indonesia |
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Type Oral Presentation |
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Theme 18th Asian Colloquium in Nephrology (18th ACN 2019) |
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Topic Dialysis: Haemodialysis |
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Main Author Riri Andri Muzasti1 |
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Presenting Author Riri Andri Muzasti1 |
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Co-Author Suhardjono 2 Bambang Purwanto3 Rosita Juwita Sembiring4 |
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Department / Institution / Country Internal Medicine, Division of Nephrology and Hypertension / Universitas Sumatera Utara / Indonesia1 Internal Medicine, Division of Nephrology and Hypertension / Universitas Indonesia / Indonesia2 Internal Medicine, Division of Nephrology and Hypertension / Universitas Negeri Surakarta / Indonesia3 Clinical Pathology / Universitas Sumatera Utara / Indonesia4 |
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Abstract Content: Introduction, Method, Result, Conclusion Introduction: Alpha 2-Heremans-Schmid glycoprotein (AHSG) is a circulating plasma protein and plays an essential role in bone and vascular mineralization as confirmed by AHSG deficient murine model. The role of AHSG gene polymorphisms to aortic calcification on hemodialysis patients was inconsistent. Unfortunately, there has been no data on AHSG gene polymorphisms as a risk factor for aortic calcification in Indonesia. To clarify precise association among AHSG gene Thr256Ser single-nucleotide polymorphisms and aortic calcification, ee performed this study Method: Patients on stable regular hemodialysis treatment more than thirty months were included in a cross-sectional study at Rasyida Renal Hospital Medan. Lateral spine X-rays were performed to evaluate the aortic calcification. Genotyping for the polymorphisms was carried out using polymerase chain reaction and restriction fragment length polymorphism techniques. Result: Aortic calcification was detected in 69.8% of patients. A total of 106 patients, 49 (46.2 %) had CC (Thr/Thr), 54 (51.0%) had CG (Thr/Ser) and 3 (2.8%) had GG (Ser/Ser) polymorphism. 22 (29.7 %), 49 (66.2%) and 3 (4.1%) patients with aortic calcification had CC (Thr/Thr), CG (Thr/Ser) and GG (Ser/Ser) polymorphism, respectively. The overall results showed that Thr256Ser polymorphism was associated with an increased risk for aortic calcification (OR = 12.8, 95% CI 4.3 – 37.5, P = 0.001). Conclusion: These results suggest that AHSG genotype variations could be a potential candidate for identifying individuals at increased risk of aortic calcification on Indonesian regular hemodialysis patient, especially in Medan population. |