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Title Risk Factor of New-Onset Diabetes Mellitus after Kidney Transplantation(NODAT) |
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Type Poster Presentation |
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Theme 18th Asian Colloquium in Nephrology (18th ACN 2019) |
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Topic Transplantation |
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Main Author Lee-Moay Lim1 4 |
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Presenting Author Jer-Ming Chang1 4 |
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Co-Author Jer-Ming Chang1 4 Lan-Fang Kung2 Hung-Tien Kuo1 3 |
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Department / Institution / Country Division of Nephrology, Department of Internal Medicine / Kaohsiung Medical University Hospital / Taiwan (台灣)1 Department of Nursing / Kaohsiung Medical University Hospital / Taiwan (台灣)2 Faculty of Renal Care, College of Medicine / Kaohsiung Medical University / Taiwan (台灣)3 College of Medicine / Kaohsiung Medical University / Taiwan (台灣)4 |
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Abstract Content: Introduction, Method, Result, Conclusion Introduction The development of new-onset diabetes mellitus after transplantation (NODAT) is a well-established metabolic complication which is related to inferior outcomes1,2. NODAT becomes one of the risk factors for cardiovascular events and graft rejection, which are associated with reduced patients and graft survival3,4. Various risk factors have been identified in the development of NODAT, including: age, ethnicity, gender, obesity, hepatitis C seropositivity and immunosuppressive drugs5. In this study, we investigated the risk factor for NODAT in a retrospective cohort from our institution.
Method This retrospective observational study population consisted of Kidney transplant recipients followed-up in a medical center in Southern Taiwan from January 1999 till Dec 2017. Kidney transplant recipients without the history of diabetes prior to transplantation were enrolled. The baseline characteristic and transplantation related profiles were collected by the time of enrollment. We examined the risk factor for NODAT after kidney transplantation using multivariate logistic regression analysis. P<0.05 was considered as statistically significant. Result A total of 221 kidney transplant recipients were enrolled, of which 48 (21.7%) developed NODAT during follow-up. Transplant recipients with NODAT were older (57.52±9.52 years-old), and with higher body mass index (BMI )(23.5±4.7 kg/m2) before transplantation compare than those without NODAT. Using multivariate analysis adjusted for confounding factors, higher BMI before transplantation is associated with increased risk of NODAT (OR= 1.106, P=0.031). Conclusion Obesity before the initiation of kidney transplantation were strong predictors for NODAT. Earlier identification of the risk factors regarding NODAT may assist physician in planning effective educational strategies in the pre-transplant setting in order to improve readiness for the challenges of post-transplant care and to optimize transplantation outcomes. |