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Title The Protective Effects of Probiotic against Heavy Metal Toxicity |
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Type Poster Presentation |
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Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
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Topic Detoxification of Environmental Pollutants by Probiotics |
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Main Author Wei Chen1 |
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Presenting Author Wei Chen1 |
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Co-Author |
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Department / Institution / Country School of Food Science and Technology, Jiangnan University / State Key Laboratory of Food Science and Technology / China (中国)1 |
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Background and Rationale Heavy metal (such as lead and cadmium) pollution is one of the oldest environmental problems and remains a serious health concern today. Recently, Probiotics have been reported to play a role against heavy metal toxicity. |
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Objectives: Indicates the purpose of the study The goal of our study was to evaluate the effects of probiotic against heavy metal toxicity, and to understand the underlying protective mechanism. |
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Methodology: Describe pertinent experimental procedures In vitro studies were conducted to screen strains with good heavy metal tolerant and binding abilities. Acute and chronic heavy metal exposure animal models were further established to understand the in vivo protection of probiotics and the related mechanism |
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Results: Summarize the results of the research Some specific probiotics such as Lactobacillus plantarum CCFM8610 and CCFM8661 were screened out for their good heavy metal binding ability, tolerance, antioxidative capacity and acid and bile salt tolerance. These strains could effectively decrease the mortality of mice, increase the heavy metal levels in the feces, reduce hepatic and renal metal accumulation, alleviate tissue oxidative stress, and ameliorate tissue histopathological changes. The mechanism can be attributed to metal sequestration, gut barrier protection, immune regulation and oxidative stress alleviation |
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Conclusions: State the main conclusions Our studies suggested that probiotics can be considered a new dietary therapeutic strategy against heavy metal toxicity. |