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Title Effects of Fructo-Oligosaccharides on the Intestinal Micro-Ecology of Constipation Induced By Loperamide in BALB/C Mice |
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Type Poster Presentation |
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Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
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Topic Development of Probiotic and Prebiotic Foods, Medical Foods, Supplements and Drugs |
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Main Author lin wang1 |
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Presenting Author lin wang1 gang wang1 |
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Co-Author gang wang1 Jianxin zhao1 hao zhang1 wei chen1 |
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Department / Institution / Country School of Food Science and Technology / Jiangnan University / China (中国)1 |
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Background and Rationale Constipation is one of the most common gastrointestinal complaints worldwide. |
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Objectives: Indicates the purpose of the study The aim of this study was to evaluate the effects of fructo-oligosaccharide (FOS) at dosages of 0.8, 4 g/d/kg bw and 8 g/d/kg bw on the composition and activity of the microbiota in the gut of mice with constipation induced by loperamide. |
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Methodology: Describe pertinent experimental procedures BALB/c mice were given FOS by gavage once per day for 8 days. Changes in intestinal flora and metabolic activities were measured to evaluate the effects of the FOS. |
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Results: Summarize the results of the research FOS increased the concentrations of acetic, propionic, butyric acids and the total acid. Acetic and butyric acids were found to have the most significant effects on constipation. The gut microbiotas were dominated by Firmicutes, Bacteroidetes and Actinobacteria. At the genus level, FOS treatment increased the relative abundance of Lactobacillus and Bifidobacterium. The relative abundance of Odoribacter, Alistipes and Bacteroides in faeces decreased in the FOS-fed mice groups. |
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Conclusions: State the main conclusions In conclusion, our results demonstrate that FOS, administered as a dietary supplement, modulate the composition of gut microbiota and increase the concentration of short-chain fatty acids in the faeces of mice with constipation. |