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Title Predominant Gut Lactobacillus .Mmurinus Strain Mediates the Anti-inflammaging Effects in Calorie Restricted Mice |
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Type Poster Presentation |
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Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
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Topic Translational Microbiome Studies |
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Main Author Chenhong Zhang1 |
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Presenting Author Chenhong Zhang1 |
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Co-Author Fengwei Pan1 Liping Zhao1 Liying Zhang1 Min Li1 |
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Department / Institution / Country School of Life sciences and Biotechnology / Shanghai Jiao Tong University / China (中国)1 |
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Background and Rationale Calorie restriction (CR), which exerts a potent anti-inflammaging effect, has been demonstrated to induce dramatic changes in the gut microbiota. It remains a question whether the modulated gut microbiota contributes to the attenuation of inflammation by CR and which members of the microbial community are the key mediators. |
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Results: Summarize the results of the research Here, we report that a unique Lactobacillus-predominated microbial community was rapidly attained in mice within 2 weeks of CR, which decreased the levels of circulating microbial antigens and systemic inflammatory markers such as tumour necrosis factor-alpha (TNF-a). Lactobacillus murinus CR147, an isolate in the most abundant operational taxonomic unit (OTU) enriched by CR, downregulated interleukin-8 production in tumor necrosis factor-alpha (TNF-α)-stimulated Caco-2 cells and significantly increased the lifespan and the brood size of the nematode Caenorhabditis elegans. In gnotobiotic mice colonized with the gut microbiota from old mice, this strain decreased their intestinal permeability and serum endotoxin load, consequently attenuating the inflammation induced by the old microbiota. |
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Conclusions: State the main conclusions Our study demonstrated that a strain of Lactobacillus murinus was promoted in CR mice and causatively contributed to the attenuation of ageing-associated inflammation. |