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Title Timing of First Probiotic Exposure During Infancy and the Risk of Celiac Disease in Genetically at Risk Children: TEDDY Study |
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Type Poster Presentation |
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Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
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Topic Probiotic and Prebiotic Clinical Research, From Newborns to Elderly |
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Main Author Ulla Uusitalo1 |
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Presenting Author Ulla Uusitalo1 |
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Co-Author Xiang Liu1 Carin Andren Aronsson2 Jimin Yang1 Edwin Liu3 Jill M Norris4 Suvi M Virtanen5 6 Daniel Agardh7 TEDDY Study Group1 |
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Department / Institution / Country Pediatrics / University of South Florida / United States1 Clinical Sciences / Lund University / Sweden (Sverige)2 Digestive Health Institute / University of Colorado Denver / United States3 Epidemiology / Colorado School of Public Health / United States4 Nutrition / National Institute for Health and Welfare / Finland (Suomi)5 Social Sciences / University of Tampere / Finland (Suomi)6 Clinical Sciences / Lund University / Sweden (Sverige)7 |
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Background and Rationale The preventive effect of probiotics on celiac disease remains unresolved. |
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Objectives: Indicates the purpose of the study The objective of this study was to examine the association between timing of first probiotic exposure by the age of 1 year and risk of celiac disease. |
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Methodology: Describe pertinent experimental procedures Newborns at genetic risk for celiac disease selected from general population followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study were annually screened for tissue transglutaminase autoantibodies (tTGA). For the purposes of this study, celiac disease was defined as having a Marsh score >1 or having a persistently tTGA level >100 U if a biopsy was not performed. Use of probiotics was monitored using questionnaires and diaries. Time-to-event analysis examined the association between timing of first probiotic exposure and the risk of celiac disease adjusting for potential confounders. |
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Results: Summarize the results of the research Among 6520 TEDDY participants screened for tTGA, 455 (7%) were diagnosed with celiac disease at the median age of 4.3 (IQR 3.2-6.2) years. Exposure to probiotics in the first year of life was reported for 1460 children, but it did not affect the risk of celiac disease (HR=1.10; 95%CI 0.85, 1.41; p=0.48).The time of first probiotic exposure did not predict celiac disease among children exposed before 12 weeks of age (HR=0.93; 95% CI 0.86, 1.01, p=0.07). However, among those exposed after 12 weeks, the risk increased 4% (HR=1.04; 95%CI 1.02, 1.07; p=0.002) for every week of probiotic delay. |
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Conclusions: State the main conclusions Overall, exposure to probiotics in infancy does not appear to protect from celiac disease. However, timing to first probiotic exposure may be important and its association with celiac disease needs to be further explored. |