|
Title A Synbiotic Mixture of Scgos/Lcfos and Bifidobacterium Breve M-16V Is Able To Restore the Delayed Colonization by Bifidobacterium in C-Section Delivered Infants |
|
Type Poster Presentation |
|
Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
|
Topic Probiotic and Prebiotic Clinical Research, From Newborns to Elderly |
|
Main Author Christophe LAY3 |
|
Presenting Author Christophe LAY3 |
|
Co-Author Mei Chien Chua 1 Anne E. N. Goh1 Wen Chin Chiang 1 Rao Rajeshwar1 Jan Knol4 5 Nipon Khemapech2 Voranush Chongsrisawat2 |
|
Department / Institution / Country KK Women and children Hospital, Singapore / KK Women and children Hospital, Singapore / Singapore1 Chulalongkorn Memorial Hospital, Bangkok, Thailand / Chulalongkorn Memorial Hospital, Bangkok, Thailand / Thailand (ไทย)2 Danone Nutricia Research / Danone Nutricia Research / Singapore3 Danone Nutricia Research / Danone Nutricia Research / Netherlands4 Wageningen University / Wageningen University / Netherlands5 |
|
Background and Rationale C-section born infants have a compromised gut microbiota at birth. Epidemiological data have indicated associations between C-section and the development of immune and metabolic disorders. Nutritional modulation of the gut microbiota may aid to reduce the disease risk associated with C-section. |
|
Objectives: Indicates the purpose of the study The objective of this study was to determine the effect of a specific synbiotic mixture in restoring the delayed colonization by Bifidobacterium in C-section delivered infants. |
|
Methodology: Describe pertinent experimental procedures In a multi-country double-blind, controlled study, 153 infants born by elective C-section were randomised to receive (1) an infant formula supplemented with short-chain galacto-oligosaccharide/ long-chain fructo-oligosaccharides (scGOS/lcFOS) and B. breve M-16V, or (2) a formula supplemented with scGOS/lcFOS, or (3) a control formula from birth until age 4 months. Thirty infants born vaginally were studied in parallel. Stool samples were collected to determine the effect of the intervention at day 3, day 5, week 4, week 8, week 12, week 16, and week 22 (6 weeks post-intervention). The proportion of bifidobacteria, different Bifidobacterium species including the probiotic strain were determined with molecular tools. pH and SCFA were also measured in the stool samples. |
|
Results: Summarize the results of the research We confirmed the delayed colonization by Bifidobacterium in C-section delivered infants. The synbiotic supplementation resulted in a higher proportion of Bifidobacterium from day 3/5 (P<0.0001) till week 8 (P=0.041) and a reduction of Enterobacteriaceae from day 3/5 (P=0.002) till week 12 (P=0.016) compared to the control group. This was accompanied with higher acetate and a lower fecal pH. In the synbiotic group, B. breve M-16V was still detected in 38.7 % of the infants at week 22.
|
|
Conclusions: State the main conclusions An infant formula supplemented with scGOS/lcFOS and B. breve M-16V supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants. |