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Title Milk Microbiota Core During First 8 Months of Lactation in Healthy Mothers from China |
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Type Poster Presentation |
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Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
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Topic Translational Microbiome Studies |
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Main Author Carlos Gómez Gallego1 |
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Presenting Author Carlos Gómez Gallego1 |
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Co-Author M. Carmen Collado2 Ai Zhao3 Kaisa M. Linderborg4 Shengjie Tan3 Baoru Yang4 Seppo Salminen1 Yumei Zhang3 |
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Department / Institution / Country Functional Foods Forum / University of Turku / Finland (Suomi)1 Department of Biotechnology / Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC) / Spain (España)2 Department of Nutrition and Food Hygiene / School of Public Health, Peking University / China (中国)3 Food Chemistry and Food Development, Department of Biochemistry / University of Turku / Finland (Suomi)4 |
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Background and Rationale Due to the differences in microbiota development between breastfed and formula- fed children and the higher risk for some diseases in formula-fed children, supplementation of formula with probiotics is an important field of research. However, breast milk is a dynamic fluid which is difficult to mimic. The composition changes along lactation and a complex microbiome is composed of hundreds of different bacteria, whose contribution to infant development has not been elucidated yet. |
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Objectives: Indicates the purpose of the study Our aim was to characterize milk microbiota changes during lactation in healthy mothers from China. |
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Methodology: Describe pertinent experimental procedures Longitudinal milk microbiota composition and diversity from 12 healthy mothers was analyzed by 16S gene sequencing. |
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Results: Summarize the results of the research Higher interindividual microbiota variation was observed among mothers and within mothers at different time points. Colostrum microbiota was dominated by Staphylococcus, Acinetobacter and Streptococcus; early milk and mature by Acinetobacter, Pseudomonas and Enterobacteriaceae; and late milk by Acinetobacter, Stenotrophomonas and Enterobacteriaceae. In addition, significant changes (p < 0.05) were found along lactation with an increase in Gammaproteobacteria group and a reduction in Firmicutes, Bacilli, Staphylococcus and Streptococcos. No differences in microbial diversity and richness during lactation were found. A stable microbial core from birth to 8 months of age was found. Nine genera were present at all the time points: Acinetobacter, Lactobacillus, Pseudomonas, Propionibacterium, Rothia, Sphingomonas, Staphylococcus, Spirosoma and Streptococcus, with changes in the abundance depending of the time point. |
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Conclusions: State the main conclusions Despite the high inter-individual variability, there is a milk microbiota core during lactation. The potential biological effect of milk microbiota core needs be identified in order to understand their impact on infant health. Such a role includes the development of infant gastrointestinal tract and immune system, leading to the development of novel infant formulas supplemented with probiotics. |