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Title A Practical Guide for the Use of Probiotics in the Prevention of Antibiotic-Associated Diarrhea in the Netherlands |
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Type Poster Presentation |
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Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
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Topic Probiotic and Prebiotic Clinical Research, From Newborns to Elderly |
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Main Author Valeria Agamennone1 |
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Presenting Author Valeria Agamennone1 |
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Co-Author Cyrille Krul1 Ger Rijkers2 Remco Kort1 3 4 |
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Department / Institution / Country Microbiology and Systems Biology / Netherlands Organization for Applied Scientific Research (TNO) / Netherlands1 Science / University College Roosevelt / Netherlands2 Micropia / Artis / Netherlands3 Molecular Cell Biology / VU University Amsterdam / Netherlands4 |
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Background and Rationale The efficacy of probiotics in the prevention of antibiotic-associated diarrhea (AAD) has been proven by several clinical studies. Although individual healthcare professionals may recommend their use alongside antibiotic therapy, no official agreement exists around the prescription of probiotics in The Netherlands. |
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Objectives: Indicates the purpose of the study We aimed at providing evidence-based recommendations to clinicians and patients in The Netherlands for the choice of probiotics to prevent AAD. |
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Methodology: Describe pertinent experimental procedures To compile the guide, we followed a workflow consisting of four steps: (1) selection of a relevant medical condition and assessment of the role of probiotics (preventive or curative), (2) identification of effective probiotics through a systematic review of relevant clinical studies, (3) compilation of a list of available probiotic products, and (4) recommendation of probiotic products matching effective formulations. The selection of clinical trials to review was based on specific inclusion criteria. We reviewed randomized, double-blind and placebo-controlled studies, including a clear definition of AAD, and during which probiotics were administered for at least the entire duration of antibiotic therapy. |
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Results: Summarize the results of the research Through review of thirty-two clinical trials satisfying the inclusion criteria, we identified seven single or multiple-strain probiotic formulations effective for the prevention of AAD. Lactobacillus rhamnosus GG was the most effective strain. From a list of all probiotic dairy products and food supplements available in The Netherlands, we selected for recommendation those matching, both in probiotic strain and number of colony-forming units, the effective formulations. We identified eight probiotic products for recommendation, including six food supplements and one dairy product. Two products based on Lactobacillus rhamnosus GG received a strong recommendation as their effect was supported by three clinical studies. |
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Conclusions: State the main conclusions We developed a practical guide that informs healthcare professionals and patients on the efficacy of probiotic products to prevent AAD and on the availability of such products in The Netherlands. |