Background: The Vaccine COVID-19 infodemic can lead the misunderstanding about the vaccine in community, and increase the unacceptance rate of the program. This study aims to investigate the correlation between demographic factors and COVID-19 vaccine literacy.

Method: A cross-sectional survey through online survey was conducted among 252 respondents. Functional, communicative, critical health literacy, age, gender, and level of education was measured. The vaccine health literacy was used questionnaire by HLVa-IT English version - Health Literacy about Vaccination in adulthood in Italian. The rank spearman test was used to measure the correlation of demographic factors and COVID-19 Vaccine HL.

Result: Education has a positive significant correlation with functional HL (p: 0,001; r: 0,55), Critical HL (p: 0,045; r: 0,16), and overall COVID-19 vaccine HL (p: 0,028; r: 0,174). Age has a positive significant correlation with communicative Hl (p:0,014; r: 0,193), Critical HL (p: 0,042; r: 0,161), and overall COVID-19 vaccine HL (p: 0,002; r: 0,239). While gender has no correlation with HL.

Conclusion: Assessing vaccine health literacy is important which can be useful to adapt medical communication strategies, for a better understanding of the value of immunization especially for this pandemic.