Abstract Preview
Abstract
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Title The Commensal Bacterium Lactobacillus Plantarum Rescues the Developmental Delay of Drosophila Melanogaster Due to Limiting Amino Acids |
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Type Poster Presentation |
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Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
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Topic Translational Microbiome Studies |
Authors
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Main Author Theodore Grenier1 |
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Presenting Author Theodore Grenier1 |
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Co-Author Francois Leulier1 |
Authors' Institution
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Department / Institution / Country Biology / Institut de Génomique Fonctionnelle de Lyon / France1 |
Content
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Background and Rationale The association formed by Drosophila melanogaster and the bacterium Lactobacillus plantarum is a model of mutualistic interaction between microbes and animal hosts. Previous data show that upon nutrient scarcity, certain strains of L. plantarum are able to rescue the developmental delay of Drosophila larvae. However, the exact mechanism underlying this growth promoting effect of L. plantarum remains elusive. |
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Objectives: Indicates the purpose of the study We wished to understand how L. plantarum is able to rescue the developmental delay of its host in situation of nutrient scarcity. |
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Methodology: Describe pertinent experimental procedures In this study, we replaced our commonly used complex diet based on inactivated yeast with a chemically defined diet, which allowed us to finely control its nutritional composition. We performed developmental timing experiments using Germ-Free larvae and larvae mono-associated with L. plantarum. We compared the effect of L. plantarum on different chemically defined diets to identify the nutrients involved in the growth-promoting effect of L. plantarum.
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Results: Summarize the results of the research We showed that L. plantarum is specifically able to compensate for amino acids scarcity. More specifically, we found that L. plantarum can rescue scarcity in limiting amino acids, such as arginine, possibly by producing them and providing them to the larva. |
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Conclusions: State the main conclusions Our study provides an interesting model to finely understand how commensal bacteria increase their host’s ability to cope with nutritional challenges. |
Requires Audio or Video system for Presentation?: No
