Abstract Preview
Abstract
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Title Probiotic Lactobacillus Casei Shirota as a Potential Adsorbent to Prevent Human Dietary Aflatoxin Exposure |
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Type Poster Presentation |
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Theme Probiotics and Prebiotics: Excellence in Science and Clinical Translation |
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Topic Detoxification of Environmental Pollutants by Probiotics |
Authors
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Main Author Mohd Redzwan Sabran1 |
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Presenting Author Mohd Redzwan Sabran1 |
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Co-Author Rosita Jamaluddin1 Mohd Sokhini Abd Mutalib1 Zuraini Ahmad2 Jia-Sheng Wang3 Min-Su Kang3 Nurul 'Aqilah Abdul Rahman1 Elham Nikbakht Nasrabadi1 |
Authors' Institution
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Department / Institution / Country Department of Nutrition and Dietetics / Universiti Putra Malaysia / Malaysia1 Department of Biomedical Science / Universiti Putra Malaysia / Malaysia2 Department of Environmental Health Science / The University of Georgia / United States3 |
Content
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Background and Rationale Aflatoxin is produced by Aspergillus species of fungi and ubiquitously found in many food commodities. The concepty of probiotic-mediated detoxification is proposed as a strategy to prevent dietary aflatoxin exposure. It is hypothesized that probiotic Lactobacillus casei Shirota (LcS) acts as adsorbent and prevents aflatoxin absorption in the gastrointestinal tract. |
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Objectives: Indicates the purpose of the study This research investigated the effectiveness of supplementation of beverages containing LcS to prevent human dietary aflatoxin exposure and reduce circular production of serum AFB1-lysine adduct (AFB1-lys) and urinary AFM1 (uAFM1). |
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Methodology: Describe pertinent experimental procedures Seventy-one subjects (n=71) with detectable uAFM1 were recruited. The study design was randomized, double-blind, cross-over, placebo-controlled study with two 4-week intervention phases. In the 1st phase, subjects either consumed beverages containing LcS or placebo drinks, twice/day. Following a 2-week wash-out period, the intervention was crossed-over and continued for another 4 weeks (2nd phase). Blood and urine were collected every two weeks to analyze AFB1-lys and uAFM1, respectively. |
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Results: Summarize the results of the research The 4-week probiotic intervention did not reduce aflatoxin biomarkers’ concentration. A stratified analysis was further performed by choosing only subjects with high concentration of aflatoxin biomarkers at baseline. There were 30 subjects (n=30) with AFB1-lys >6.68 pg/mg albumin and the concentration was significantly different (F2,30=4.525; P=0.023; partial ƞ2=0.135) throughout the 4-week probiotic intervention, but not with the placebo. After 2 weeks of intervention, the AFB1-lys concentration decreased significantly (P=0.008), with 20.8% of reduction. A similar observation was found among 33 subjects (n=33) with median uAFM1 concentration >0.088 pg/µmol creatinine. The concentration was significantly different (P=0.048), showing a decreasing trend of uAFM1 concentration during the 4-week probiotic intervention. |
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Conclusions: State the main conclusions As a functional food, probiotic is an immerse value in the area of detoxification and decontamination biotechnology. Thus, a longer intervention study is warranted to investigate the effect of continuous consumption of LcS to prevent human dietary aflatoxin exposure. |
Requires Audio or Video system for Presentation?: No
